2. Signaling Pathways
  3. GPCR/G Protein
  4. Angiotensin Receptor

Angiotensin Receptor

Angiotensin Receptor

Related Products

PDF 1.86 MB

Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.

Angiotensin Receptor Isoform Specific Products:

Angiotensin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-13948F1
    Angiotensin II human, FAM-labeled
    		Activator 99.53%
    Angiotensin II human, FAM-labeled (Angiotensin II, FAM-labeled ; Ang II, FAM-labeled ; DRVYIHPF, FAM-labeled) is a biological active peptide. (FAM labeled HY-13948)
    Angiotensin II human, FAM-labeled
  • HY-102093
    ZD 7155(hydrochloride)
    		Antagonist 99.88%
    ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.
    ZD 7155(hydrochloride)
  • HY-P1515A
    Angiotensin II (3-8), human TFA
    		Agonist 99.90%
    Angiotensin II (3-8), human (TFA) is a less effective agonist at the angiotensin AT1 receptor.
    Angiotensin II (3-8), human TFA
  • HY-P1540A
    Angiotensin III, human, mouse TFA
    		99.63%
    Angiotensin III, human, mouse (TFA) is an angiotensin.
    Angiotensin III, human, mouse TFA
  • HY-18706
    trans-Tranilast
    		Inhibitor 98.99%
    trans-Tranilast (trans-MK-341) is an antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis.
    trans-Tranilast
  • HY-15477A
    YS-49 monohydrate
    		Inhibitor 99.56%
    YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors.
    YS-49 monohydrate
  • HY-B0205S
    Candesartan-d4
    		Antagonist 98.85%
    Candesartan-d4 is the deuterium labeled Candesartan, which is an angiotensin II receptor antagonist.
    Candesartan-d<sub>4</sub>
  • HY-B0202S
    Irbesartan-d4
    		Antagonist 99.46%
    Irbesartan-d4 is the deuterium labeled Irbesartan, which is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist.
    Irbesartan-d<sub>4</sub>
  • HY-P5127
    CNP-38
    		99.63%
    CNP-38 is a C-type natriuretic peptide.
    CNP-38
  • HY-19732
    BIBS 39
    		Antagonist 99.70%
    BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist.
    BIBS 39
  • HY-131276
    Olmesartan lactone impurity
    		Antagonist 99.27%
    Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study.
    Olmesartan lactone impurity
  • HY-P3910
    [Val4] Angiotensin III
    		Activator 98.51%
    [Val4] Angiotensin III is an angiotension III peptide. [Val4] Angiotensin III is a potent full agonist of Gαq and βarr2 response, with pEC50 values of 8.31 and 8.44, respectively.
    [Val4] Angiotensin III
  • HY-12765S
    Losartan-d4 (carboxylic acid)
    		Antagonist 98.17%
    Losartan-d4 (carboxylic acid) is the deuterium labeled Losartan (EXP-3174), which is an angiotensin II receptor antagonist.
    Losartan-d<sub>4</sub> (carboxylic acid)
  • HY-P1769
    Angiotensin II (5-8), human
    		99.68%
    Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II. Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney.
    Angiotensin II (5-8), human
  • HY-B0205S1
    Candesartan-d5
    		Antagonist
    Candesartan-d5 is the deuterium labeled Candesartan. Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.
    Candesartan-d<sub>5</sub>
  • HY-17004S
    Olmesartan-d4
    		Chemical 98.83%
    Olmesartan-d4 is the deuterium labeled Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.
    Olmesartan-d<sub>4</sub>
  • HY-114161A
    H-Val-Pro-Pro-OH TFA
    		Inhibitor ≥98.0%
    H-Val-Pro-Pro-OH (TFA), a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM.
    H-Val-Pro-Pro-OH TFA
  • HY-18204S
    Valsartan-d9
    		Antagonist 99.33%
    Valsartan-d9 is deuterium labeled valsartan. Valsartan is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research[1].
    Valsartan-d<sub>9</sub>
  • HY-10259
    PD 123319
    		Antagonist
    PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
    PD 123319
  • HY-114412A
    TD-0212 TFA
    		Antagonist 98.44%
    TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP.
    TD-0212 TFA
Cat. No. Product Name / Synonyms Application Reactivity
Angiotensin Receptor Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.